Education

Research Interest

The mechanisms that regulate vascular reactivity in physiological and pathophysiological conditions are to a large extent, unresolved. We utilize a combination of molecular, physiological, and pharmacological tools, including gene suppression, Ca²⁺ imaging, patch clamp electrophysiology, tension and pressure myography, and intravital imaging to investigate functional macromolecular complexes that regulate arterial contractility and their roles in vascular diseases.

Research Support

04/15/09 - 03/31/14: NIH/NHLBI K01HL096411, "Vasoregulation by IP₃ receptor coupling to TRPC channels" P.I.

Selected Publications

1. Thomas-Gatewood CM, Neeb ZP, Adebiyi A, Bannister JP, Jaggar JH. TMEM16A channels generate Ca²⁺-activated Cl^- currents in cerebral artery smooth muscle cells. American Journal of Physiology. Heart and Circulatory Physiology 2011; (In Press).
2. Adebiyi A, McNally EM, Jaggar JH. Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice. American Journal of Physiology. Heart and Circulatory Physiology 2011; (In Press).
3. Liang GH, Adebiyi A, Leo MD, McNally EM, Leffler CW, Jaggar JH. Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels. American Journal of Physiology. Heart and Circulatory Physiology 2011; 300:H2088-H2095.
4. Bannister JP, Thomas-Gatewood CM, Neeb ZP, Adebiyi A, Cheng X, Jaggar JH. Ca_V1.2 channel N-terminus splice variants modulate functional surface expression in resistance-size artery smooth muscle cells. Journal of Biological Chemistry 2011; 286:15058-15066.
5. **Adebiyi A, Narayanan D, Jaggar JH. Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells. Journal of Biological Chemistry 2011; 286:4341-4348. ** Science Signaling Editor?s Choice:  Gough NR. Coupled by Caveolin. Science Signaling 2011; 4 (160): ec50. **Featured paper: North American Vascular Biology Organization Publications Alert, March 2011
6. Zhao G, Neeb ZP, Leo MD,  Pachuau J, Adebiyi A, Ouyang K, Chen J, Jaggar JH. Type 1 IP₃ receptors activate BK_Ca channels via local molecular coupling in arterial smooth muscle cells. Journal of General Physiology 2010; 136:283-291.
7. Adebiyi A, Zhao G, Narayanan D, Thomas-Gatewood CM, Bannister JP, Jaggar JH.  Isoform-selective physical coupling of TRPC3 channels to IP₃ receptors in smooth muscle cells regulates arterial contractility. Circulation Research 2010; 106:1603-1612.
8. Bannister JP, Adebiyi A, Zhao G, Narayanan D, Thomas CM, Feng JY, Jaggar JH. Smooth muscle cell alpha2delta-1 subunits are essential for vasoregulation by Ca_V1.2 channels. Circulation Research 2009; 105:948-955.
9. Zhao G, Adebiyi A, Blaskova E, Xi Q, Jaggar JH. Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, Ca²⁺ signals, and vasoconstriction in cerebral arteries. American Journal of Physiology. Cell Physiology 2008; 295:C1376-1384.
10. Adebiyi A, McNally EM, Jaggar JH. Sulfonylurea receptor-dependent and -independent pathways for K_ATP channel opener-mediated vasodilation Molecular Pharmacology 2008; 74:736-743.
11. Xi Q, Adebiyi A, Zhao G, Chapman KE, Waters CM, Hassid A, Jaggar JH. IP₃ constricts cerebral arteries via IP₃ receptor-mediated TRPC3 channel activation and independently of sarcoplasmic reticulum Ca²⁺ release. Circulation Research 2008; 102:1118-1126.
12. Zhao G, Adebiyi A, Xi Q, Jaggar JH. Hypoxia reduces K_Ca channel activity by inducing Ca²⁺ spark uncoupling in cerebral artery smooth muscle cells. American Journal of Physiology. Cell Physiology 2007; 292(6):C2122-128.
13. Adebiyi A, Zhao G, Cheranov SY, Ahmed A, Jaggar JH. Caveolin-1 abolishment attenuates the myogenic response in murine cerebral arteries. American Journal of Physiology. Heart and Circulatory Physiology 2007; 292(3):H1584-1592.
14. Li A, Adebiyi A, Leffler CW, Jaggar JH. K_Ca channel insensitivity to Ca²⁺ sparks underlies fractional uncoupling in newborn cerebral artery smooth muscle cells. American Journal of Physiology. Heart and Circulatory Physiology 2006; 291: H1118-1125.