University of Sheffield, Sheffield, UK, 1991-1995, Ph.D., Potassium Channels
University of Vermont, Burlington, VT, 1995-1997, Postdoc., Gastrointestinal Physiology
University of Vermont, Burlington, VT, 1997-1999, Postdoc., Vascular Physiology
The focus of my laboratory is to study mechanisms that regulate the diameter of small arteries and arterioles that modulate systemic blood pressure and organ blood flow. Smooth muscle cells within the vascular wall determine arterial diameter. Our major focus is to investigate the functional significance of arterial smooth muscle cell plasma membrane and intracellular ion channels and local and global calcium signals in regulating arterial smooth muscle cell contractility. Research in the laboratory involves a multi-faceted approach, studying events at molecular, cellular and intact artery levels. Techniques include patch clamp electrophysiology, rapid confocal calcium imaging, conventional calcium imaging, immunofluoresence, FRET, diameter measurement of pressurized arteries, use of knockout models, and molecular biology. Please click on My Laboratory for more detailed information.
04/01/08 - 03/31/17, NIH R01 HL67061, Vascular control by K+ channel trafficking. P.I.
Xi, Q, Cheranov, SY, & Jaggar, JH. (2005). Mitochondria-derived reactive oxygen
species dilate cerebral arteries by activating Ca2+ sparks.Circulation Research, 97, 354-362.PMID: 16020754. Received
Editorial Commentary by D. Gutterman. Circulation Research, 2005; 97(4):
JH, Li, A, Parfenova, H, Liu, J, Umstot, ES, Dopico, AM, & Leffler, CW. (2005). Heme is a carbon monoxide receptor for
large-conductance Ca2+-activated K+ channels. Circulation
Research, 97, 805-812. PMID: 16166559
X, Liu, J, Asuncion-Chin, M, Blaskova, E, Bannister, JP, Dopico, AM, &
Jaggar, JH. (2007). A novel CaV1.2 N-terminus expressed
in smooth muscle cells of resistance-size arteries modifies channel regulation
by auxiliary subunits.Journal of
Biological Chemistry, 282, 29211-29221.PMID: 17699517
Xi, Q, Adebiyi, A, Zhao, G, Chapman, KE, Waters,
CM, Hassid, A, & Jaggar, JH. (2008).
IP3 constricts cerebral
arteries via IP3 receptor-mediated TRPC3 channel activation and
independently of sarcoplasmic reticulum Ca2+ release.Circulation Research,102(9), 1118-1126.PMID: 18388325
Bannister, JP, Adebiyi, A, Zhao, G,
Narayanan, D, Thomas, CM, Feng, JY, & Jaggar, JH. (2009).Smooth muscle cell ?2?-1 subunits are essential for
vasoregulation by CaV1.2 channels.Circulation Research, 105, 948-955.PMID: 19797702
Adebiyi, A, Zhao, G, Narayanan, D, Thomas,
CM, Bannister, JP, & Jaggar, JH.(2010).Isoform-selective physical coupling of TRPC3
channels to IP3 receptors in smooth muscle cells regulates arterial
Xi, Q, Pfeffer, L, & Jaggar, JH.(2010).Mitochondria control functional CaV1.2
expression in smooth muscle cells of cerebral arteries.Circulation Research, 107(5),
Research Editors? Pick.Circulation Research Featured Article.Faculty of 1000 Medicine Must Read
G, Neeb, Z, Leo, MD, Pachuau, J, Adebiyi, A, Ouyang, K, Chen, J, & Jaggar,
JH. (2010).Type 1 IP3 receptors activate BKCa
channels via local molecular coupling in arterial smooth muscle cells.Journal of General Physiology, 136(3),
283-291. PMID: 20713546.Journal
of General Physiology Journal Club Article by Mujica and González. Selected for Journal of General Physiology Facebook Discussion.
A, Narayanan, D, & Jaggar, JH.(2011).Caveolin-1 assembles type 1 inositol
1,4,5-trisphosphate receptors and canonical transient receptor potential 3
channels into a functional signaling complex in arterial smooth muscle
cells.Journal of Biological
Chemistry, 286(6), 4341-4348.PMID:
21098487.Editors Choice:Coupled by Caveolin.Science Signaling, Vol. 4, Issue 160, p. ec50. Featured in NAVBO Publications Alert,
JP, Thomas-Gatewood, CM, Neeb, ZP, Adebiyi, A, Cheng, X, & Jaggar, JH.(2011).Cav1.2 channel N-terminus splice variants modulate functional
surface expression in resistance-size artery smooth muscle cells.Journal of Biological Chemistry, 286(17),
15058-15066.PMID: 21357696. Received Perspective by Joern R Steinert. Journal of Physiology, 2012; 590 (14):3213-3214.
JP, Bulley S, Narayanan D, Thomas-Gatewood C, Luzny P, Pachuau J, & Jaggar
upregulation of ?2?-1 elevates arterial smooth muscle cell Cav1.2
channel surface expression and cerebrovascular constriction in genetic
60:1006-1015.PMID: 22949532. Commentary by Luis F. Santana and Jose L.Mercado.Hypertension, 2012; 60:894-895.
Bulley S, Neeb ZP, Burris SK, Bannister JP, Thomas-Gatewood
CM, Jangsangthong W, & Jaggar JH.(2012). TMEM16A channels contribute to the
myogenic response in cerebral arteries.Circulation
Research, 111(8):1027-1036. PMID: 22872152.
A, Thomas-Gatewood CM, Leo MD,Kidd MW,
Neeb ZP, & Jaggar JH. (2012) An
elevation in physical coupling of type 1 IP3 receptors to TRPC3
channels constricts mesenteric arteries in genetic hypertension.Hypertension,
60:1213-1219. PMID: 23045459.
Bannister JP, Leo, MD, Narayanan, D, Jangsangthong W, Nair A, Evanson KW, Pachuau J, Gabrick KS, Boop FA, Jaggar JH. (2013)The CaV1.2 channel C-terminus fragment is a bi-modal vasodilator.Journal of Physiology 591(12):2987-2998.PMID: 23568894.
Leo MD, Bannister JP, Narayanan D, Nair A, Grubbs JE, Gabrick KS, Boop FA, Jaggar JH. (2014) Dynamic Regulation of ?1 subunit Trafficking Controls Vascular Contractility.Proc Natl Acad Sci USA111(6):2361-2366. PMID: 24464482.